Histamine Illness

So last Saturday, the 17th, was my last dose of Duloxetine. I had been miserable with more histamine and canker sores and tongue sore and swollen on the right side and same on my throat during that time.

It all got worse and worse so I stopped taking it, and 4 days later it wasn’t as bad, but it took until yesterday for my tongue to go down.

BUT…

My stomach was super acid sloshing that whole time too, and finally hubby got me Kirkland Acid Controller (compare to Pepcid AC) and later on Thursday.

On Thursday morning I got up and blah, I felt weaker and acidy and my head hurt, I had trouble wanting to drink water like I usually do in the morning. Ugh.

Much later hubby came home with the meds.

I felt very sloshy oh so horrible by the time I had the meds, I couldn’t take one then. I took one later in the evening when I could drink water again, and felt much better finally, and slept well.

I didn’t eat much at all that day. Then Friday morning, so much worse, but I made instant mashed potatoes with butter and some salt on top around 12p.m., and oh it felt so good to eat and I wished I had more, and felt SO GOOD. Half an hour later, Oh God I felt so full suddenly.

Now that feeling I know with Pots flares, but I didn’t eat that much and hadn’t for over a day at that point.

Queasy stayed later when the over eating feel stopped. Going to sleep was miserable because I had headaches all day, not super bad, just there and as long as I didn’t think of them, fine sort of.

But overnight by 3:30a.m. I was hurting very bad, and waking just after 6am, I took Excedrin and went back to sleep.

Around 8am I had a cup of coffee, enjoyed that, then eventually queasy set in again and absolutely digging migraine on the left, and it got so bad and became a switcher migraine, which are usually very fucking intense when that happens, and yes, it was. That drove me to take Eletriptan at 9:34a.m. today.

So now it is 11:42a.m. The Eletriptan should be out of me, I don’t know if it is because of my digestion is wacky with the queasy and acid slosh.

I did take the Kirkland and Allegra this morning together. Hopes that all will go well in the future doing that, when needed.

I haven’t always been acidy, it just happens sometimes, and does when have migraine often, but not always every day, but has been so since I started Duloxetine … in general Histamine through the roof.

So my illness now is maybe mostly histamine, not a bug. That’s my overwhelming feeling about it all.

Histamine running rampant gives me headaches, queasiness yes, makes total sense it is MCAS. So the Duloxetine started it up again. I don’t have it TOTALLY that bad usually but it can get bad do to this or that, and that is the Duloxetine.

Doctor didn’t say anything when I talked about it months ago. I don’t know if he understands it or could do the things to diagnose it or not.

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Edit: 10-24-26 1:18pm: I posted this on my chart chart a little bit ago:

Started taking on October 9, 2026Comments: Histamine flare-up, canker sores, tongue and throat on right side swelling and sore, sinus dripping worse than usual. I do think I have MCAS and this is a fairly bad. Flare of it that is continuing on now. I stopped taking this med after 9 days of doses, and the mouth and throat stuff got a lot better after 4 days, but I'm still in a huge flare that makes me more head-achy and miserable, queasy and weak because I don't like eating and when I do I feel too full from anything. Classic misery all my life like this, I take 1/2 a Benadryl pill to help, and still take Allegra every day, and I just hate this. More migraines as well, I do think histamine is a trigger. So I'm DOA hahaha.